منابع مشابه
Epidemiology of Haemophilus influenzae type b invasive disease in Wales.
OBJECTIVE To investigate the epidemiology of invasive disease due to Haemophilus influenzae type b, the clones responsible, and the antibiotic resistance of the isolates. DESIGN Prospective population based analysis of clinical and epidemiological data collected for Gwynedd during 1980-90 and in the whole of Wales during 1988-90. SETTING 19 hospitals in Wales; all medical microbiology labor...
متن کاملHaemophilus Influenzae Type B Disease
Before the introduction of effective vaccines, H. influenzae, type b (Hib) was the leading cause of bacterial meningitis and other invasive bacterial disease among children less than 5 years of age. In 1997, ten confirmed cases of invasive disease caused by the serotype b strain of H. influenzae were reported. This is the first year that the number of cases increased since the conjugate vaccine...
متن کاملNeonatal invasive Haemophilus influenzae disease in England and Wales: epidemiology, clinical characteristics, and outcome.
BACKGROUND Nontypeable Haemophilus influenzae (NTHi) frequently causes noninvasive upper respiratory tract infections in children but can cause invasive disease, mainly in older adults. An increased burden of invasive NTHi disease in the perinatal period has been reported by a number of studies. Here we describe the epidemiology, clinical characteristics, and outcome of neonatal invasive H. inf...
متن کاملImmunogenicity and Efficacy of Different Haemophilus influenzae type b Vaccines
Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. Despite the availability of new and more powerful antibiotics children with Hib meningitis still suffer from high mortality or morbidity. The emergence of multir...
متن کاملPrevention of Haemophilus influenzae type b disease.
Haemophilus influenzae type b (Hib) is the leading cause of meningitis in children < 5 years of age. The majority of cases of Hib occur in infants < 2 years of age. Until recently the only vaccine available against this disease contained the pure polysaccharide (PRP) of Hib (Hib-PRP vaccine). The Hib-PRP vaccine was demonstrated to be efficacious in infants > 18 months of age but not below that...
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ژورنال
عنوان ژورنال: BMJ
سال: 1991
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.303.6800.441